Stains
SIRT1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 December 2015, last major update January 2012

Copyright: (c) 2012-2015, PathologyOutlines.com, Inc.

Cite this page: SIRT1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssirt1.html. Accessed December 8th, 2016.
Definition / General
  • Silent Information Regulator Transcript 1
  • Encodes a member of the sirtuin family of proteins
  • Nicotinamide adenine dinucleotide (NAD) dependent deacetylase
  • Can both promote and suppress tumorigenesis (N A J Med Sci 2011;4:104)
Pathophysiology
  • Energy metabolism: senses energy/nutrient status via NAD+/NADH ratio, functions as transcriptional repressor via histone deacetylation in the nucleus; modifies acetylation level of p53, NF-KB, FOX0; SIRT1 activation stimulates PGC1α, which activates mitochondrial biogenesis and metabolism and increases insulin sensitivity (Nutr Metab (Lond) 2011;8:91 [Epub ahead of print])
  • BCR-ABL of CML activates SIRT1 expression in hematopoietic progenitor cells (Blood 2011 Dec 29 [Epub ahead of print])
  • Important in epigenetic gene silencing; inhibition reactivates silenced genes; associated with CpG island methylator phenotype-high MSI-high colon cancer (Mod Pathol 2009;22:922
Diagrams / Tables

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Localization and functions of the human sirtuins Sirt1, Sirt2 and Sirt3

Clinical Features
Interpretation
  • Nuclear staining
Uses by Pathologists
  • None at this time
Micro Images

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SIRT1 expression in colorectal cancer

Positive Staining - Disease