Stains
SIRT1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update January 2012

Copyright: (c) 2012-2018, PathologyOutlines.com, Inc.

PubMed Search: SIRT1[TI] review[ptyp]

Cite this page: Pernick, N. SIRT1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssirt1.html. Accessed October 20th, 2018.
Definition / general
  • Silent Information Regulator Transcript 1
  • Encodes a member of the sirtuin family of proteins
  • Nicotinamide adenine dinucleotide (NAD) dependent deacetylase
  • Can both promote and suppress tumorigenesis (N A J Med Sci 2011;4:104)
Pathophysiology
  • Energy metabolism: senses energy/nutrient status via NAD+/NADH ratio, functions as transcriptional repressor via histone deacetylation in the nucleus; modifies acetylation level of p53, NF-KB, FOX0; SIRT1 activation stimulates PGC1α, which activates mitochondrial biogenesis and metabolism and increases insulin sensitivity (Nutr Metab (Lond) 2011;8:91)
  • BCR-ABL of CML activates SIRT1 expression in hematopoietic progenitor cells (Blood 2012;119:1904)
  • Important in epigenetic gene silencing; inhibition reactivates silenced genes; associated with CpG island methylator phenotype-high MSI-high colon cancer (Mod Pathol 2009;22:922)
Diagrams / tables

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Localization and
functions of the
human sirtuins
Sirt1, Sirt2 and Sirt3

Clinical features
Interpretation
  • Nuclear staining
Uses by pathologists
  • None at this time
Microscopic (histologic) images

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SIRT1 expression in colorectal cancer

Positive staining - disease