Topic Completed: 1 January 2012

Minor changes: 8 March 2019

Copyright: 2012-2018,, Inc.

PubMed Search: SIRT1[TI] review[ptyp]

Nat Pernick, M.D.
Page views in 2019: 43
Page views in 2020 to date: 14
Cite this page: Pernick N. SIRT1. website. Accessed June 4th, 2020.
Definition / general
  • Silent Information Regulator Transcript 1
  • Encodes a member of the sirtuin family of proteins
  • Nicotinamide adenine dinucleotide (NAD) dependent deacetylase
  • Can both promote and suppress tumorigenesis (N A J Med Sci 2011;4:104)
  • Energy metabolism: senses energy/nutrient status via NAD+/NADH ratio, functions as transcriptional repressor via histone deacetylation in the nucleus; modifies acetylation level of p53, NF-KB, FOX0; SIRT1 activation stimulates PGC1α, which activates mitochondrial biogenesis and metabolism and increases insulin sensitivity (Nutr Metab (Lond) 2011;8:91)
  • BCR-ABL of CML activates SIRT1 expression in hematopoietic progenitor cells (Blood 2012;119:1904)
  • Important in epigenetic gene silencing; inhibition reactivates silenced genes; associated with CpG island methylator phenotype-high MSI-high colon cancer (Mod Pathol 2009;22:922)
Diagrams / tables

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Localization and
functions of the
human sirtuins
Sirt1, Sirt2 and Sirt3

Clinical features
  • Nuclear staining
Uses by pathologists
  • None at this time
Microscopic (histologic) images

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SIRT1 expression in colorectal cancer

Positive staining - disease
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