Stains
SOX2


Topic Completed: 1 December 2011

Revised: 8 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: SOX2[title]

Nat Pernick, M.D.
Page views in 2018: 1,143
Page views in 2019 to date: 661
Cite this page: Pernick N. SOX2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssox2.html. Accessed July 17th, 2019.
Definition / general
  • Transcription factor at 3q26.33, essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Also known as SRY (sex determining region Y)-box 2 is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Skin: embryonal / fetal (left), adult (right)

Breast carcinoma: various

Breast carcinoma


Lung adenocarcinoma

Skin tumors: Merkel cell carcinoma (left), melanoma (right)

Squamous cell carcinoma

Positive staining - disease
Negative staining
  • Choriocarcinoma (testis), seminoma (mediastinum, testis), yolk sac tumors (mediastinum, testis)
  • CNS germinoma (Am J Surg Pathol 2006;30:1613), lymphoma
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