Stains
SOX2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 December 2015, last major update December 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: SOX2[title]

Definition / General
  • Transcription factor at 3q26.33, essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Also known as SRY (sex determining region Y)-box 2 is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior
Clinical Features
Uses by Pathologists
Micro Images

Images hosted on other servers:

Skin: embryonal/fetal (left), adult (right)

Breast carcinoma: various

Lung adenocarcinoma

Skin tumors: Merkel cell carcinoma (left), melanoma (right)

Squamous cell carcinoma



Images hosted on Nature.com:

Fetal brain

Breast carcinoma

CNS immature (left) and mature (right) teratomas

Testicular mixed germ cell tumors

Positive Staining - Disease
Negative Staining
  • Choriocarcinoma (testis), seminoma (mediastinum, testis), yolk sac tumors (mediastinum, testis)
  • CNS germinoma (Am J Surg Pathol 2006;30:1613), lymphoma