Stains
SOX2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update December 2011

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: SOX2[title]

Cite this page: Pernick, N. SOX2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssox2.html. Accessed August 14th, 2018.
Definition / general
  • Transcription factor at 3q26.33, essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Also known as SRY (sex determining region Y)-box 2 is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells
  • Marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Skin: embryonal / fetal (left), adult (right)

Breast carcinoma: various

Breast carcinoma


Lung adenocarcinoma

Skin tumors: Merkel cell carcinoma (left), melanoma (right)

Squamous cell carcinoma

Positive staining - disease
Negative staining
  • Choriocarcinoma (testis), seminoma (mediastinum, testis), yolk sac tumors (mediastinum, testis)
  • CNS germinoma (Am J Surg Pathol 2006;30:1613), lymphoma