Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update November 2013

Copyright: (c) 2013-2018,, Inc.

PubMed Search: SOX9[title]

Page views in 2018: 614
Page views in 2019 to date: 59
Cite this page: Pernick, N. SOX9. website. Accessed January 22nd, 2019.
Definition / general
  • Sex determining region Y (SRY)-related high mobility groupbox 9
  • Transcription factor linked to hedgehog pathways, plays a central role in development and differentiation of multiple cell lineages
  • Downstream molecule of beta-catenin
  • Master regulator of chondrogenesis
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Duodenum: normal mucosa
(figs D, E, F)

Duodenum: nonampullary adenoma
(figs D, E, F)

Duodenum: nonampullary adenocarcinoma (figs D, E, F)

Liver: hepatocellular carcinoma and normal

Lung: normal and non small cell lung cancer

Skin: scalp

Skin : psoriasis, keratoacanthoma, carcinoma

Skin: TISH analysis

Testis: androgen insensitivity and Sertoli cell only syndromes, normal spermatogenesis