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Molecular markers

STAT3

Author: Nat Pernick, M.D.

Last author update: 1 November 2013

Last staff update: 24 October 2022

Copyright: 2013-2024, PathologyOutlines.com, Inc.

PubMed Search: STAT3

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Table of Contents

Definition / general | Clinical features | Uses by pathologists | Microscopic (histologic) images

Cite this page: Pernick N. STAT3. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsstat3.html. Accessed April 20th, 2024.

Definition / general

Signal transducer and activator of transcription 3
In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators (GeneCards: STAT3 [Accessed 10 August 2018])
STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis (Wikipedia: STAT3 [Accessed 10 August 2018])
Acts as central transcription factor downstream of multiple cytokine and growth factor receptors, regulating antimicrobial responses and cell survival (JAKSTAT 2013;2:e23435)

Clinical features

Dominant negative STAT3 mutation causes Hyper-IgE syndrome (Nature 2007;448:1058)
Activated in ALK+ large B cell lymphoma (Mod Pathol 2013;26:1329, Am J Surg Pathol 2013;37:780)
Somatic STAT3 mutations identified in large granular lymphocytic leukemia (N Engl J Med 2012;366:1905)
Single nucleotide polymorphisms in STAT3 gene are associated with autoimmune thyroid disease in Chinese patients (Funct Integr Genomics 2013;13:455)
In colon, epithelial STAT3 plays a critical role in inflammation-induced tumor progression by regulating leukocytic recruitment, especially the infiltration of Treg cells (Neoplasia 2013;15:998)

Uses by pathologists