Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update November 2013

Copyright: (c) 2013-2018,, Inc.

PubMed Search: STAT3[title]

Cite this page: Pernick, N. STAT3. website. Accessed October 20th, 2018.
Definition / general
  • Signal transducer and activator of transcription 3
  • In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators (GeneCards: STAT3 [Accessed 10 August 2018])
  • STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis (Wikipedia: STAT3 [Accessed 10 August 2018])
  • Acts as central transcription factor downstream of multiple cytokine and growth factor receptors, regulating antimicrobial responses and cell survival (JAKSTAT 2013;2:e23435)
Clinical features
Uses by pathologists
  • No significant clinical uses as this time
Microscopic (histologic) images

Images hosted on other servers:

Bladder: normal & carcinoma


Lung: small cell lung cancer

Lymph node: diffuse large B cell lymphoma

Skin: psoriasis vulgaris

Stomach: normal & cancer