Stains
STAT3



Topic Completed: 1 November 2013

Revised: 8 March 2019

Copyright: 2013-2018, PathologyOutlines.com, Inc.

PubMed Search: STAT3[title]

Nat Pernick, M.D.
Page views in 2018: 410
Page views in 2019 to date: 123
Cite this page: Pernick N. STAT3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsstat3.html. Accessed July 19th, 2019.
Definition / general
  • Signal transducer and activator of transcription 3
  • In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators (GeneCards: STAT3 [Accessed 10 August 2018])
  • STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis (Wikipedia: STAT3 [Accessed 10 August 2018])
  • Acts as central transcription factor downstream of multiple cytokine and growth factor receptors, regulating antimicrobial responses and cell survival (JAKSTAT 2013;2:e23435)
Clinical features
Uses by pathologists
  • No significant clinical uses as this time
Microscopic (histologic) images

Images hosted on other servers:

Bladder: normal & carcinoma

Colon

Lung: small cell lung cancer

Lymph node: diffuse large B cell lymphoma

Skin: psoriasis vulgaris

Stomach: normal & cancer

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