Stains
Survivin

Author Nat Pernick, M.D. (see Authors page)

Revised: 10 December, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Survivin[title]

General
  • Inhibitor of apoptosis protein; may also enhance proliferative activity of tumor cells
  • Overexpression enhances cell survival
Interpretation
  • Cytoplasmic staining
Positive Staining - Normal
  • Fetal tissues
Positive Staining - Disease
  • Hepatocellular carcinoma, endometrial carcinoma
Negative Staining
  • Most normal, terminally differentiated tissue