Stains
TAK1 / MAP3K7

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 December 2015, last major update November 2013

Copyright: (c) 2013 - 2015, PathologyOutlines.com, Inc.

PubMed Search: TAK1[title] or MAP3K7[title]

Definition / General
  • TGF-β activated kinase-1 (Tak1), is a serine/threonine kinase and MAP3 kinase; is a key regulator in inflammatory and immune signaling pathways (Trends Pharmacol Sci 2012;33:522)
  • Activated by TGF-β; also TNF, IL1, CD40 ligand, toll-like receptors, T- and B-cell receptors; upon activation, activates IκK, p38 MAPK, c-jun N-terminal kinase, leading to activation of NF-κB and activator protein-1 transcription factors, which mediate various inflammatory cytokines involved in inflammation, immunity and cell death (Blood 2012;120:347)
  • Putative prostate tumor suppressor gene
  • TAK1 is an essential component in genotoxic stress-induced NF-κB activation, associated with chemoresistance (Apoptosis 2013;18:1224)
    • TAK1 ubiquitination plays critical roles in regulation of Doxycycline induced NF-κB activation (Cell Signal 2013;25:247)
  • Involved in at least five signaling cascades that modulate ischemic brain damage; inhibition may be protective against ischemic stroke (Exp Neurol 2013;239:68)
  • Also associated with human longevity (Age (Dordr) 2013;35:1357)
Uses by Pathologists
  • No specific uses at this time
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