Topic Completed: 1 December 2011

Revised: 8 March 2019

Copyright: 2002-2015,, Inc.

Nat Pernick, M.D.
Page views in 2018: 134
Page views in 2019 to date: 135
Cite this page: Pernick N. T-bet. website. Accessed September 18th, 2019.
Definition / general
  • Master regulator of helper T cells type 1
  • As a transcription factor, also regulates development and cytotoxic function of NK cells
Uses by pathologists
Microscopic (histologic) images

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Pre-B lymphoblastic lymphoma of kidney (left), skin (right)

Positive staining - normal
  • CD4+ T cells, some B cells
Positive staining - disease
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