Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update December 2011

Copyright: (c) 2002-2015,, Inc.

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Cite this page: T-bet. website. Accessed January 20th, 2019.
Definition / general
  • Master regulator of helper T cells type 1
  • As a transcription factor, also regulates development and cytotoxic function of NK cells
Uses by pathologists
Microscopic (histologic) images

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Pre-B lymphoblastic lymphoma of kidney (left), skin (right)

Positive staining - normal
  • CD4+ T cells, some B cells
Positive staining - disease