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Stains

T-bet


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 December 2011, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Master regulator of helper T cells type 1
● As a transcription factor, also regulates development and cytotoxic function of NK cells

Uses
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● May be useful to detect minimal hairy cell leukemia infiltrates in bone marrow biopsies (Am J Surg Pathol 2007;31:1181)
● Does not appear to be useful in differentiating hairy cell leukemia from marginal zone lymphoma (Am J Clin Pathol 2011;136:390)

Micro images
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Rheumatoid synovium

Positive staining - normal
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● CD4+ T cells, some B cells

Positive staining - disease
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● Extranodal NK/T-cell lymphoma, nasal type, and peripheral T-cell lymphoma (Hum Pathol 2011;42:1319)
● Some B cell non-Hodgkin lymphomas (Am J Clin Pathol 2004;122:292)

End of Stains > T-bet


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