Cite this page: Pernick N. Telomerase. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainstelomerase.html. Accessed December 13th, 2019.
Definition / general
- A ribonucleoprotein multisubunit enzyme complex that functions as a specialized reverse transcriptase, to synthesize telomeric repeats (TTAGGG) to the 3 ends of human chromosomes
- Components of telomerase: RNA template, telomerase associated protein, human telomerase reverse transcriptase (hTERT)
- RNA template and telomerase associated protein are expressed ubiquitously
- hTERT protein expression is highly regulated, generally correlates with telomerase activity; reexpression correlates with laryngeal carcinogenesis (Mod Pathol 2005;18:406)
- hTERT is a nuclear stain