Stains
Telomerase



Topic Completed: 1 June 2005

Revised: 8 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Telomerase[title]
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Cite this page: Pernick N. Telomerase. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainstelomerase.html. Accessed March 20th, 2019.
Definition / general
  • A ribonucleoprotein multisubunit enzyme complex that functions as a specialized reverse transcriptase, to synthesize telomeric repeats (TTAGGG) to the 3 ends of human chromosomes
  • Components of telomerase: RNA template, telomerase associated protein, human telomerase reverse transcriptase (hTERT)
  • RNA template and telomerase associated protein are expressed ubiquitously
  • hTERT protein expression is highly regulated, generally correlates with telomerase activity; reexpression correlates with laryngeal carcinogenesis (Mod Pathol 2005;18:406)
Interpretation
  • hTERT is a nuclear stain
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