Stains
Telomerase

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update June 2005

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Telomerase[title]

Cite this page: Pernick, N. Telomerase. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainstelomerase.html. Accessed August 17th, 2018.
Definition / general
  • A ribonucleoprotein multisubunit enzyme complex that functions as a specialized reverse transcriptase, to synthesize telomeric repeats (TTAGGG) to the 3 ends of human chromosomes
  • Components of telomerase: RNA template, telomerase associated protein, human telomerase reverse transcriptase (hTERT)
  • RNA template and telomerase associated protein are expressed ubiquitously
  • hTERT protein expression is highly regulated, generally correlates with telomerase activity; reexpression correlates with laryngeal carcinogenesis (Mod Pathol 2005;18:406)
Interpretation
  • hTERT is a nuclear stain