Topic Completed: 1 June 2005

Revised: 8 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: Tenascin[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Tenascin. website. Accessed September 23rd, 2019.
Definition / general
  • Also called tenascin C
  • Large glycoprotein of extracellular matrix, synthesized by fibroblasts, composed of epidermal growth factor like repetitions
  • May function in epithelial-mesenchymal interactions
  • Expressed during embryogenesis, growth, wound healing, inflammation
  • Increased in carcinoma of Ampulla of Vater, breast, colon, lung, prostate
  • Pheochromocytoma: strong expression associated with malignancy (Am J Surg Pathol 2001;25:1419)
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