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Stains
Topoisomerase II alpha (TOP2A)

Reviewer: Semir Vranic, M.D. (see Reviewers page)
Revised: 20 July 2013, last major update June 2010
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Pathophysiology
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Uses by pathologists
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Micro images
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Rectal crypts in normal tissue: #1-biopsy at 6 am; #2-biopsy at 6 pm (note different staining based on time of biopsy)


Breast carcinoma

Breast carcinomas with
high and low expression


Hodgkin lymphoma

Liver: hepatocellular carcinoma


Lung cancer: small cell (+) versus adenocarcinoma (focal +)


Meningiomas (fig A, C)

Myeloma (fig A)


Nasal: various

Ovarian tumors


Pancreatic endocrine neoplasm

Pituitary adenoma

Pituitary carcinoma


Prostate: hormone insensitive

Prostate: squamous cell carcinoma (fig b)

Prostate: various


Seminoma

Thyroid carcinoma: tall
cell and papillary variant

Thyroid: anaplastic carcinoma


Positive staining - normal
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Positive staining - benign and borderline lesions
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Positive staining - carcinoma
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Negative staining
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Molecular images
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Breast carcinoma: FISH of HER2 and TOP2A

TOP2A CEP17 FISH no gene amplification

End of Stains > Topoisomerase II alpha (TOP2A)


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