Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 November 2015, last major update June 2005
Copyright: (c) 2003-2015,, Inc.
Definition / General
  • Structural protein involved in assembly of mitotic spindles
  • Increased expression is associated with increased mitotic activity
  • Cytoplasmic staining in mantle cell lymphoma
Positive Staining - Normal
  • Germinal centers (but not mantle zones) of benign lymph nodes
Micro Images

Staining in tonsil (fig 2a), mantle cell lymphoma (2d)