Topic Completed: 1 May 2013

Revised: 2 May 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Tyrosinase[TI] review[ptyp]

Lauren N. Stuart, M.D., M.B.A.
Page views in 2018: 706
Page views in 2019 to date: 558
Cite this page: Stuart L. Tyrosinase. website. Accessed September 17th, 2019.
Definition / general
  • Also called T311 (for immunohistochemistry)
  • Melanocyte specific antigen important in melanin synthesis and melanosome formation
  • Interpretation: cytoplasmic staining
Uses by pathologists
  • Identification of melanocytic neoplasms
Microscopic (histologic) images

Images hosted on other servers:

Normal skin
prominent melanocytes (a);
melanoma - positive
homogenous tumor cells (b)

Melanoma (image 3, cytology)

Renal angiomyolipoma (image 4, weak)

Positive staining - normal
Positive staining - disease
Negative staining
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