Author: Lauren Stuart, M.D., M.B.A. (see Authors page)

Revised: 1 December 2015, last major update May 2013

Copyright: (c) 2002-2015,, Inc.

Cite this page: Tyrosinase. website. Accessed May 22nd, 2018.
Definition / general
  • Also called T311 (for immunohistochemistry)
  • Melanocyte specific antigen important in melanin synthesis and melanosome formation
  • Interpretation: cytoplasmic staining
Uses by pathologists
  • Identification of melanocytic neoplasms
Microscopic (histologic) images

Images hosted on other servers:

Normal skin-prominent melanocytes (a);
melanoma-positive homogenous tumor cells (b)

Melanoma (image 3, cytology)

Renal angiomyolipoma (image 4, weak)

Positive staining - normal
Positive staining - disease
Negative staining