Author: Lauren Stuart, M.D., M.B.A. (see Authors page)

Revised: 10 August 2018, last major update May 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Tyrosinase[TI] review[ptyp]

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Cite this page: Stuart, L. Tyrosinase. website. Accessed January 18th, 2019.
Definition / general
  • Also called T311 (for immunohistochemistry)
  • Melanocyte specific antigen important in melanin synthesis and melanosome formation
  • Interpretation: cytoplasmic staining
Uses by pathologists
  • Identification of melanocytic neoplasms
Microscopic (histologic) images

Images hosted on other servers:

Normal skin
prominent melanocytes (a);
melanoma - positive
homogenous tumor cells (b)

Melanoma (image 3, cytology)

Renal angiomyolipoma (image 4, weak)

Positive staining - normal
Positive staining - disease
Negative staining