Urates / uric acid

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

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Cite this page: Urates / uric acid. website. Accessed January 22nd, 2019.
Definition / general
  • Uric acid crystals seen in acid urine
  • Urates present in tissue as sodium urate, but soluble in aqueous solutions and slightly soluble in weak alcoholic solutions, so tissue must be fixed in 95%/100% alcohol to prevent leaching of urates
  • Urates are stained black by GMS
  • Sodium urate crystals are birefringent on polarization
Microscopic (histologic) images

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Uric acid crystals, polarized, with red plate