Urates / uric acid

Topic Completed: 1 June 2005

Minor changes: 11 March 2019

Copyright: (c) 2003-2015,, Inc.

Nat Pernick, M.D.
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Cite this page: Pernick N. Urates / uric acid. website. Accessed August 4th, 2020.
Definition / general
  • Uric acid crystals seen in acid urine
  • Urates present in tissue as sodium urate, but soluble in aqueous solutions and slightly soluble in weak alcoholic solutions, so tissue must be fixed in 95%/100% alcohol to prevent leaching of urates
  • Urates are stained black by GMS
  • Sodium urate crystals are birefringent on polarization
Microscopic (histologic) images

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Uric acid crystals, polarized, with red plate

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