Stains
Urates / uric acid

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

Cite this page: Urates / uric acid. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsurates.html. Accessed December 2nd, 2016.
Definition / General
  • Uric acid crystals seen in acid urine
  • Urates present in tissue as sodium urate, but soluble in aqueous solutions and slightly soluble in weak alcoholic solutions, so tissue must be fixed in 95%/100% alcohol to prevent leaching of urates
  • Urates are stained black by GMS
  • Sodium urate crystals are birefringent on polarization
Micro Images

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Uric acid crystals, polarized, with red plate