Uroplakin III

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 November 2015, last major update June 2005
Copyright: (c) 2003-2015,, Inc.
PubMed Search: Uroplakin III[title]
Definition / General
  • One of 4 members of uroplakin family
  • Transmembrane protein expressed by urothelial lining cells (umbrella cells) within apical plaques of cell membrane
  • Specific but only 50% sensitive for urothelial lesions (Am J Surg Pathol 2003;27:1)
Uses by Pathologists
Micro Images

Urothelial carcinoma (invasive)

Positive Staining - Normal
  • Urothelium, particularly umbrella cells
Positive Staining - Disease
Negative Staining