Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 August 2012, last major update April 2012 - IN PROGRESS
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
● One of 4 members of uroplakin family
● Transmembrane protein expressed by urothelial lining cells (umbrella cells) within apical plaques of cell membrane
● Specific but only 50% sensitive for urothelial lesions (Am J Surg Pathol 2003;27:1)
Uses by pathologists
● Characterize urothelial lesions and differentiate from prostatic (Hum Pathol 2002;33:1136), penile (Am J Surg Pathol 2012;36:869), vulvar (Hum Pathol 2002;33:545) or renal lesions
● May be applicable for forensic urine identification by immunohistochemistry (J Forensic Sci 2010;55:742)
Urothelial carcinoma (invasive)
Positive staining - normal
● Urothelium, particularly umbrella cells
Positive staining - disease
● Urothelial lesions
● Ovarian Brenner tumor (Am J Surg Pathol 2003;27:1434)
● Bladder: small cell carcinoma (Am J Surg Pathol 2003;27:1), squamous lesions (Virchows Arch 2011;458:301)
● Prostate: adenocarcinoma
End of Stains > Uroplakin III
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).