Uroplakin III

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Uroplakin III[title]

Cite this page: Uroplakin III. website. Accessed March 29th, 2017.
Definition / General
  • One of 4 members of uroplakin family
  • Transmembrane protein expressed by urothelial lining cells (umbrella cells) within apical plaques of cell membrane
  • Specific but only 50% sensitive for urothelial lesions (Am J Surg Pathol 2003;27:1)
Uses by Pathologists
Micro Images

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Urothelial carcinoma (invasive)

Positive Staining - Normal
  • Urothelium, particularly umbrella cells
Positive Staining - Disease
Negative Staining