Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 October 2015, last major update June 2005
Copyright: (c) 2003-2015,, Inc.
Table of Contents
Definition / General
Definition / General
  • Vascular Endothelial Growth Factor
  • Exists in 4 different homodimeric isoforms due to alternate splicing
  • Potent angiogenic growth factor that stimulates endothelial cell proliferation and induces microvessel permeability
  • Protein and mRNA are overexpressed in various tumors
  • May have prognostic significance in esophageal adenocarcinoma (Hum Pathol 2005;36:955)