Stains
VEGF

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 November 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

Table of Contents
Definition / General
Definition / General
  • Vascular Endothelial Growth Factor
  • Exists in 4 different homodimeric isoforms due to alternate splicing
  • Potent angiogenic growth factor that stimulates endothelial cell proliferation and induces microvessel permeability
  • Protein and mRNA are overexpressed in various tumors
  • May have prognostic significance in esophageal adenocarcinoma (Hum Pathol 2005;36:955)