Topic Completed: 1 June 2005

Revised: 11 March 2019

Copyright: 2003-2015,, Inc.

Nat Pernick, M.D.
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Page views in 2019 to date: 315
Table of Contents
Definition / general
Cite this page: Pernick N. VEGF. website. Accessed September 23rd, 2019.
Definition / general
  • Vascular Endothelial Growth Factor
  • Exists in 4 different homodimeric isoforms due to alternate splicing
  • Potent angiogenic growth factor that stimulates endothelial cell proliferation and induces microvessel permeability
  • Protein and mRNA are overexpressed in various tumors
  • May have prognostic significance in esophageal adenocarcinoma (Hum Pathol 2005;36:955)
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