Author: Nat Pernick, M.D. (see Authors page)
Revised: 30 November 2015, last major update June 2005
Copyright: (c) 2003-2015,, Inc.
Definition / General
  • Induces angiogenesis and lymphangiogenesis with VEFR receptor 2 (VEGFR2) and VEGFR3 (also called Flt4)
  • Associated with lymphangiogenesis and lymphatic metastasis in papillary thyroid carcinoma (Mod Pathol 2005;18:1127)
Positive Staining - Normal
  • Thyroid follicular epithelium
Micro Images

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Papillary thyroid carcinoma-diffuse and intense staining (fig 1f)