von Willebrand factor (vWF)

Topic Completed: 1 June 2005

Minor changes: 11 March 2019

Copyright: 2003-2015,, Inc.

Nat Pernick, M.D.
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Cite this page: Pernick N. von Willebrand factor (vWF). website. Accessed July 8th, 2020.
Definition / general
  • Large glycoprotein involved in platelet aggression and adhesion to subendothelial matrix
  • Somewhat sensitive (50-75%) for vascular tumors; CD31, CD34 or perhaps FLI1 are more sensitive
  • Cytoplasmic stain
  • Endothelium should be a positive internal control
Positive staining - normal
  • Endothelial cells, megakaryocytes, subendothelial connective matrix
  • Areas of tumor necrosis and hemorrhage
Positive staining - disease
  • Blood vessels in tumors, vascular tumors, metastatic osteosarcoma
Microscopic (histologic) images

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Positive staining of endothelium (fig 2A)

Additional references
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