von Willebrand factor (vWF)

Topic Completed: 1 June 2005

Minor changes: 28 August 2020

Copyright: 2003-2020,, Inc.

Nat Pernick, M.D.
Page views in 2019: 479
Page views in 2020 to date: 351
Cite this page: Pernick N. von Willebrand factor (vWF). website. Accessed September 26th, 2020.
Definition / general
  • Large glycoprotein involved in platelet aggression and adhesion to subendothelial matrix
  • Somewhat sensitive (50-75%) for vascular tumors; CD31, CD34 or perhaps FLI1 are more sensitive
  • Cytoplasmic stain
  • Endothelium should be a positive internal control
Positive staining - normal
  • Endothelial cells, megakaryocytes, subendothelial connective matrix
  • Areas of tumor necrosis and hemorrhage
Positive staining - disease
  • Blood vessels in tumors, vascular tumors, metastatic osteosarcoma
Additional references
Back to top
Image 01 Image 02