Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 29 October 2015, last major update June 2005
Copyright: (c) 2003-2013,, Inc.
Definition / General
  • Tumor suppressor gene at 11p13
  • Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
  • Involved in development of tissues from inner layer of intermediate mesoderm
  • Nuclear stain
Uses by Pathologists
  • (1) ovarian carcinoma (WT1+) vs. breast/pancreatic carcinoma (WT1 negative)
Positive Staining - Normal
  • Fallopian tube, kidney, mesothelium, ovarian granulosa cells, Sertoli cells, spleen
Positive Staining - Disease
  • Acute myeloid leukemia, cystic partially differentiated nephroblastoma, desmoplastic small round cell tumor, malignant mesothelioma, metanephric adenoma, nephrogenic rests, ovarian carcinomas (serous carcinoma [almost all], transitional, small cell, Am J Surg Pathol 2005;29:1034), peritoneal serous carcinoma involving an endometrial polyp-80% (Am J Surg Pathol 2005;29:1074), rhabdoid tumor, Wilm tumor
Negative Staining
Micro Images

Images hosted on other servers:

Metanephric adenoma (fig D)

Ovarian tumor subtypes