Topic Completed: 1 June 2005

Minor changes: 21 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: WT1[TI] pathology free full text[sb]

Nat Pernick, M.D.
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Cite this page: Pernick N. WT1. website. Accessed August 6th, 2020.
Definition / general
  • Tumor suppressor gene at 11p13
  • Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
  • Involved in development of tissues from inner layer of intermediate mesoderm
  • Nuclear stain
Uses by pathologists
  • (1) ovarian carcinoma (WT1+) vs. breast/pancreatic carcinoma (WT1 negative)
Positive staining - normal
  • Fallopian tube, kidney, mesothelium, ovarian granulosa cells, Sertoli cells, spleen
Positive staining - disease
  • Acute myeloid leukemia, cystic partially differentiated nephroblastoma, desmoplastic small round cell tumor, malignant mesothelioma, metanephric adenoma, nephrogenic rests, ovarian carcinomas (serous carcinoma [almost all], transitional, small cell, Am J Surg Pathol 2005;29:1034), peritoneal serous carcinoma involving an endometrial polyp-80% (Am J Surg Pathol 2005;29:1074), rhabdoid tumor, Wilm tumor
Negative staining
Microscopic (histologic) images

Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

Ovarian serous carcinoma immunoprofile

Images hosted on other servers:

Metanephric adenoma (fig D)

Ovarian tumor subtypes

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