Stromal / other tumors
Gastrointestinal autonomic nerve tumor (GANT)
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 October 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Phenotypic variant of GIST with c-kit mutations and CD117+ expression (Am J Surg Pathol 2001;25:979)
● Originally categorized as separate tumor due to ultrastructural resemblance to cells of the autonomic nervous system (Am J Surg Pathol 1993;17:887, Arch Pathol Lab Med 1986;110:309)
Electron microscopy description
● Complex interdigitating cell processes with bulbous synaptic terminals, small, dense core neurosecretory granules (uniform, 190 nm, submembrane spaces), rudimentary cell junctions, intermediate filaments
● Also extracellular skenoid fibers
Electron microscopy images
End of Stomach > Stromal / other tumors > Gastrointestinal autonomic nerve tumor (GANT)
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