GE junctional adenocarcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 9 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: gastroesophageal junctional adenocarcinoma
Cite this page: GE junctional adenocarcinoma. website. Accessed March 21st, 2018.
Definition / general
  • Based on AJCC Cancer Staging Manual (7th ed, 2010), adenocarcinoma arising in gastroesophageal junction and proximal 5 cm of stomach is staged as esophageal cancer
  • Heterogeneous group of tumors, but most arise from distal esophagus associated with Barrett's esophagus; cardia adenocarcinomas and subcardial gastric carcinomas which secondarily invade GE junction also occur
  • Distal esophageal tumors: usually men, associated with Barrett's esophagus (intestinal metaplasia) and reflux, less likely to have diffuse growth pattern, lower incidence of lymphatic spread, CK7+
  • Cardia tumors: usually men, usually not associated with Barrett's esophagus, higher frequency of diffuse pattern, although most are still intestinal
Positive stains
Differential diagnosis