Stomach - Graft versus host disease

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Stomach

Gastritis

Graft versus host disease

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Common after allogeneic bone marrow transplantation, although diagnosis based on subtle findings
● Similar histology associated with common variable immunodeficiency and X-linked agammaglobulinemia (Am J Surg Pathol 1996;20:1240)

Micro description
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● Apoptosis, gland destruction, sparse inflammatory infiltrate, granular eosinophilic debris in dilated glands (“exploding crypt cell”, 94% specific, 41% sensitive, Am J Surg Pathol 1997;21:1037)

Differential diagnosis
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● CMV, HIV

Additional references
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● Odze R, Goldblum J (2009). Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas: expert consult - online and print. Philadelphia, PA: Saunders

End of Stomach > Gastritis > Graft versus host disease

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