Graft versus host disease

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: gastric graft versus host disease
Cite this page: Graft versus host disease. website. Accessed August 21st, 2017.
Definition / general
  • Common after allogeneic bone marrow transplantation, although diagnosis based on subtle findings
  • Similar histology associated with common variable immunodeficiency and X-linked agammaglobulinemia (Am J Surg Pathol 1996;20:1240)
Microscopic (histologic) description
  • Apoptosis, gland destruction, sparse inflammatory infiltrate, granular eosinophilic debris in dilated glands ("exploding crypt cell", 94% specific, 41% sensitive, Am J Surg Pathol 1997;21:1037)
Differential diagnosis
  • CMV, HIV