Stromal / other tumors
Langerhans cell histiocytosis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 16 December 2016, last major update July 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Langerhans cell histiocytosis stomach
Cite this page: Langerhans cell histiocytosis. website. Accessed March 30th, 2017.
Definition / General
  • Rare clonal proliferation of Langerhans cells; usually affects skin or lymph nodes, rare in stomach
Case Reports
Gross Description
  • Multiple, small sessile elevations in stomach
Micro Description
  • Diffuse collection of large, polygonal cells with oval nuclei containing longitudinal grooves
  • May occur in discrete clusters resembling granulomas (Arch Pathol Lab Med 1994;118:1232), may have scattered eosinophils or multinucleated giant cells
  • No prominent nucleoli, mitotic figures rare
Positive Stains
Electron Microscopy Description
  • Birbeck granules, interdigitating cytoplasmic projections