Other nonneoplastic lesions
Proton pump inhibitors

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 November 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: proton pump inhibitors[title]
Cite this page: Weisenberg, E. Proton pump inhibitors. website. Accessed November 14th, 2018.
Definition / general
  • Includes omeprazole, lansoprazole, dexlansoprazole, esomeprazole, rabeprazole
  • Used to treat gastroesophageal reflux disease (GERD)
  • Patients may develop G cell and enterochromaffin cell-like hyperplasia, secondary to drug induced achlorhydria
  • Long-term therapy associated with fundic gland polyps (sessile, multiple, < 1.0 cm) in 17% after 3 months, in 35% after 5 months treatment
  • Polyps regress when treatment stops (Hum Pathol 2000;31:684)
Microscopic (histologic) description
  • Glandular luminal dilatation with swelling and bulging of the superficial cytoplasm of parietal cells (so-called parietal cell protrusion)
  • Glands lined by cells with serrated rather than a smooth border