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Ulcerative colitis

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Gastric involvement is rare, may occur with duodenal involvement (J Clin Gastroenterol 2004;38:46, Am J Surg Pathol 2000;24:1407)
● More common in children
● Described after total colectomy (J Clin Gastroenterol 2012 Jul 31 [Epub ahead of print])
● Crohn’s disease should be excluded
● Distinction between Crohn’s disease and ulcerative colitis may be blurred, possibly represents separate category of inflammatory bowel disease

Micro description

● Most common upper GI inflammatory pattern is focal gastritis, followed by gastric basal mixed inflammation and superficial plasmacytosis (Am J Surg Pathol 2010;34:1672)
● Variable changes include multiple tiny shallow ulcers, crypt abscess formation, increased intraepithelial lymphocytes, villous blunting
● Microscopic findings parallel remissions and relapses of colonic inflammation

End of Stomach > Gastritis > Ulcerative colitis

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