Non-neoplastic anomalies
Achalasia of cardia

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 November 2016, last major update July 2016

Copyright: (c) 2003-2016,, Inc.

PubMed Search: gastric achalasia of cardia
Cite this page: Achalasia of cardia. website. Accessed February 22nd, 2018.
Definition / general
  • Controversial diagnosis: some authors do not consider this diagnosis distinct from achalasia of esophagus
  • Rare disorder of children
  • Due to defective relaxation of the cardia and absence of peristalsis in esophageal body
  • Associated with lack of nitrous oxide nerve fibers and with lymphocytes infiltrating myenteric plexus
  • May occur as part of Allgroves syndrome (triple A syndrome, OMIM 231550, Am J Surg Pathol 2003;27:667), an autosomal recessive disorder which features achalasia, Addisonianism (ACTH insensitivity), and alacrima (lack of tears), and may have late-onset progressive neurologic symptoms; may be due to mutations of Aladin (Adracalin) gene at 12q13
Microscopic (histologic) description
  • Fibrosis between circular and longitudinal muscles, reduction in myenteric ganglia and myenteric neurons