Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Stomach

Non-neoplastic anomalies

Achalasia of cardia

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 28 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Note: some authors define achalasia as restricted to the esophagus only
● Rare disorder of children
● Due to defective relaxation of the cardia and absence of peristalsis in esophageal body
● Associated with lack of nitrous oxide nerve fibers and with lymphocytes infiltrating myenteric plexus
● May occur as part of Allgrove’s syndrome (triple A syndrome, OMIM 231550, Am J Surg Pathol 2003;27:667), an autosomal recessive disorder which features achalasia, Addisonianism (ACTH insensitivity), and alacrima (lack of tears), and may have late-onset progressive neurologic symptoms; may be due to mutations of Aladin (Adracalin) gene at 12q13

Micro description
=========================================================================

● Fibrosis between circular and longitudinal muscles, reduction in myenteric ganglia and myenteric neurons

End of Stomach > Non-neoplastic anomalies > Achalasia of cardia

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).