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Eosinophilic (allergic) gastroenteritis

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Usually children or young adults with vomiting, diarrhea, protein losing enteropathy, food sensitivity, growth failure
● Also allergic history, anemia, blood eosinophilia, increased serum IgE
● Stomach most common site, but primary eosinophilic gastritis without involvement of esophagus or duodenum is uncommon; symptoms relate to site
● Either mucosal, mural or serosal disease; mucosal biopsies may be normal when disease is primarily mural or serosal
● Ascites with eosinophilia may occur with serosal disease
● Often have positive skin tests but no anaphylactic reactions, suggestive of type IV hypersensitivity


● Steroids, diet modification, but may have multiple relapses

Micro description

● Mucosal disease: diffuse and marked eosinophils in mucosa of antrum, focally in fundus/body

Micro images

Dense eosinophilic infiltrate of lamina propria

Additional references

Am J Surg Pathol 1986;10:75, Curr Gastrenterol Rep 2004;6:436

End of Stomach > Gastritis > Eosinophilic (allergic) gastroenteritis

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