Eosinophilic gastritis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 November 2018, last major update July 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: eosinophilic (allergic) gastroenteritis
Cite this page: Weisenberg, E. Eosinophilic gastritis. website. Accessed December 16th, 2018.
Definition / general
  • Usually children or young adults with vomiting, diarrhea, protein losing enteropathy, food sensitivity, growth failure
  • Also allergic history, anemia, blood eosinophilia, increased serum IgE
  • Stomach most common site, but primary eosinophilic gastritis without involvement of esophagus or duodenum is uncommon; symptoms relate to site
  • Either mucosal, mural or serosal disease; mucosal biopsies may be normal when disease is primarily mural or serosal
  • Ascites with eosinophilia may occur with serosal disease
  • Often have positive skin tests but no anaphylactic reactions, suggestive of type IV hypersensitivity
  • Formerly known as allergic gastritis
  • Steroids, diet modification, but may have multiple relapses
Microscopic (histologic) description
  • Mucosal disease: diffuse and marked eosinophils in mucosa of antrum, focally in fundus / body
Microscopic (histologic) images

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Dense eosinophilic infiltrate of lamina propria