Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 6 September 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Rare; mixed neuroendocrine and non-neuroendocrine carcinoma
● Cells have dual differentiation, with mucus and neuroendocrine granules in cytoplasm of same cells
● 64 year old man (Arch Pathol Lab Med 2001;125:1513)
● Am J Surg Pathol 1991;15:592
Figure 1: neuroendocrine component in solid nests, trabeculae, ribbons
Figure 2: poorly differentiated gastric signet ring cell carcinoma
Figure 3: some signet ring cells showed distinct granular immunoreactivity for chromogranin
End of Stomach > Carcinoma > Amphichrine carcinoma
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