Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: carditis gastritis
Table of Contents
Definition / general
Cite this page: Carditis. website. Accessed October 18th, 2018.
Definition / general
  • Common finding: present in 75-95% of biopsies
  • Small zone of pure mucous-type glands is present in cardia of most pediatric patients, but GERD related injury and repair may contribute to expansion of this zone (Am J Surg Pathol 2002;26:1032)
  • Intestinal metaplasia present in 10-22% of unselected patients
  • Eosinophils in cardia are associated with active esophagitis (GERD)
  • Marked lymphocytic inflammation without eosinophils is associated with chronic gastritis and H. pylori infection
  • Goblet cells are associated with both GERD and H. pylori infection
  • Don't call Barrett's esophagus based only on cardia findings - associated endoscopic abnormalities must be present; however, both GERD and H. pylori induced inflammation may culminate in neoplasia
  • Distinction of ultra short segment Barrett's esophagus from carditis may be difficult (Mod Pathol 1999;12:1017)
  • Most (79%) cases of carditis have no gastritis in antrum (Am J Surg Pathol 2001;25:245)
  • Active inflammation is present in 18% (12% in low grade carditis, 57% in severe carditis), predicts associated distal gastritis and H. pylori infection