Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 1 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Common finding: present in 75-95% of biopsies
● Small zone of pure mucous-type glands is present in cardia of most pediatric patients, but GERD related injury and repair may contribute to expansion of this zone (Am J Surg Pathol 2002;26:1032)
● Intestinal metaplasia present in 10-22% of unselected patients
● Eosinophils in cardia are associated with active esophagitis (GERD)
● Marked lymphocytic inflammation without eosinophils is associated with chronic gastritis and H. pylori infection
● Goblet cells are associated with both GERD and H. pylori infection
● Don’t call Barrett’s esophagus based only on cardia findings - associated endoscopic abnormalities must be present; however, both GERD and H. pylori induced inflammation may culminate in neoplasia
● Distinction of ultra short segment Barrett’s esophagus from carditis may be difficult (Mod Pathol 1999;12:1017)
● Most (79%) cases of carditis have no gastritis in antrum (Am J Surg Pathol 2001;25:245)
● Active inflammation is present in 18% (12% in low grade carditis, 57% in severe carditis), predicts associated distal gastritis and H. pylori infection
End of Stomach > Gastritis > Carditis
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