Atrophic gastritis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 November 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: chronic (atrophic) gastritis
Cite this page: Weisenberg, E. Atrophic gastritis. website. Accessed December 11th, 2018.
Definition / general
  • Sometimes known as multifocal atrophic gastritis; formerly environmental gastritis
  • Chronic gastritis accompanied by glandular atrophy (mild, moderate, severe), usually secondary to chronic H. pylori infection
  • Initially glands are compressed, later they are destroyed, loss of acid leads to conditions conducive to bacterial growth
  • Associated with duodenal ulcer, gastric peptic ulcer
  • Degree of atrophy and intestinal metaplasia are correlated (Hum Pathol 2001;32:31)
  • Epithelial changes may become dysplastic and progress to carcinoma
Gross description
  • Thin, smooth mucosa (without rugae), prominent submucosal vessels (due to mucosal atrophy)
Microscopic (histologic) images

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Chronic atrophic gastritis with intestinal metaplasia