Stomach
Gastritis
Chronic (atrophic) gastritis

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2012

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PubMed Search: chronic (atrophic) gastritis
Cite this page: Chronic (atrophic) gastritis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachchronicatrophic.html. Accessed December 8th, 2016.
Definition / General
  • Sometimes known as multifocal atrophic gastritis; formerly environmental gastritis
  • Chronic gastritis accompanied by glandular atrophy (mild, moderate, severe), usually secondary to chronic H. pylori infection
  • Initially glands are compressed, later they are destroyed, loss of acid leads to conditions conducive to bacterial growth
  • Associated with duodenal ulcer, gastric peptic ulcer
  • Degree of atrophy and intestinal metaplasia are correlated (Hum Pathol 2001;32:31)
  • Epithelial changes may become dysplastic and progress to carcinoma
Gross Description
  • Thin, smooth mucosa (without rugae), prominent submucosal vessels (due to mucosal atrophy)
Micro Images

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Chronic atrophic gastritis with intestinal metaplasia