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Chronic (atrophic) gastritis

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 1 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Sometimes known as multifocal atrophic gastritis; formerly environmental gastritis
● Chronic gastritis accompanied by glandular atrophy (mild, moderate, severe), usually secondary to chronic H. pylori infection
● Initially glands are compressed, later they are destroyed, loss of acid leads to conditions conducive to bacterial growth
● Associated with duodenal ulcer, gastric peptic ulcer
● Degree of atrophy and intestinal metaplasia are correlated (Hum Pathol 2001;32:31)
● Epithelial changes may become dysplastic and progress to carcinoma

Gross description

● Thin, smooth mucosa (without rugae), prominent submucosal vessels (due to mucosal atrophy)

Micro images

Chronic atrophic gastritis with intestinal metaplasia

End of Stomach > Gastritis > Chronic (atrophic) gastritis

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