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Other non-neoplastic lesions

Colchicine toxicity

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 6 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Colchicine is treatment for gout; toxicity can cause chronic renal failure and death
● Binds tubulin interfering with polymerization into microtubules
● Features below are associated with toxicity only, not therapeutic colchicine without toxicity

Micro description

● Many mitotic figures, mitoses arrested in metaphase (ring formation), epithelial pseudostratification, loss of polarity, abundant crypt apoptotic bodies anywhere in GI tract, but especially in gastric antrum and duodenum with relative sparing of gastric body (Am J Surg Pathol 2001;25:1067)

Differential diagnosis

● Dysplasia: no history of colchicine

End of Stomach > Other non-neoplastic lesions > Colchicine toxicity

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