Other non-neoplastic lesions
Colchicine toxicity

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 29 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: colchicine toxicity[title]
Cite this page: Colchicine toxicity. website. Accessed October 18th, 2018.
Definition / general
  • Colchicine is treatment for gout; toxicity can cause chronic renal failure and death
  • Binds tubulin interfering with polymerization into microtubules
  • Features below are associated with toxicity only, not therapeutic colchicine without toxicity
Microscopic (histologic) description
  • Many mitotic figures, mitoses arrested in metaphase (ring formation), epithelial pseudostratification, loss of polarity, abundant crypt apoptotic bodies anywhere in GI tract, but especially in gastric antrum and duodenum with relative sparing of gastric body (Am J Surg Pathol 2001;25:1067)
Differential diagnosis
  • Dysplasia: no history of colchicine