Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Stomach

Other non-neoplastic lesions

Colchicine toxicity


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 6 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Colchicine is treatment for gout; toxicity can cause chronic renal failure and death
● Binds tubulin interfering with polymerization into microtubules
● Features below are associated with toxicity only, not therapeutic colchicine without toxicity

Micro description
=========================================================================

● Many mitotic figures, mitoses arrested in metaphase (ring formation), epithelial pseudostratification, loss of polarity, abundant crypt apoptotic bodies anywhere in GI tract, but especially in gastric antrum and duodenum with relative sparing of gastric body (Am J Surg Pathol 2001;25:1067)

Differential diagnosis
=========================================================================

● Dysplasia: no history of colchicine

End of Stomach > Other non-neoplastic lesions > Colchicine toxicity


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).