Collagenous gastritis

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: collagenous gastritis
Cite this page: Collagenous gastritis. website. Accessed October 17th, 2018.
Definition / general
  • Very rare
  • Children and young adults with severe anemia, nodular endoscopic pattern
  • Associated with collagenous colitis in adults with chronic watery diarrhea or with celiac disease
  • Case reports in patients with celiac disease (Arch Pathol Lab Med 2001;125:1579, Mod Pathol 2000;13:591)
  • Endoscopy: erosion and hemorrhages in children
Microscopic (histologic) description
  • Thick subepithelial collagen band (at least 10 microns, mean 30 microns, normal is 1 micron), often ragged at lower edge, commonly with entrapped red blood cells, fibroblasts, inflammatory cells and superficial capillaries (Am J Surg Pathol 2001;25:1174)
  • Associated with mixed inflammatory infiltrate of lamina propria and variable surface epithelial damage of cuboidal cytoplasmic changes, reactive cytoplasmic changes, reactive nuclear enlargement, subepithelial edema and erosions
  • Similar changes occur after radiation therapy and in some patients with scleroderma
Microscopic (histologic) images

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Various images

Celiac disease