Stomach - Collagenous gastritis

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Stomach

Gastritis

Collagenous gastritis

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Very rare
● Children and young adults with severe anemia, nodular endoscopic pattern
● Associated with collagenous colitis in adults with chronic watery diarrhea or with celiac disease
● Case reports in patients with celiac disease (Arch Pathol Lab Med 2001;125:1579, Mod Pathol 2000;13:591)

Endoscopy
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● Erosion and hemorrhages in children

Micro description
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● Thick subepithelial collagen band (at least 10 microns, mean 30 microns, normal is 1 micron), often ragged at lower edge, commonly with entrapped red blood cells, fibroblasts, inflammatory cells and superficial capillaries (Am J Surg Pathol 2001;25:1174)
● Associated with mixed inflammatory infiltrate of lamina propria and variable surface epithelial damage of cuboidal cytoplasmic changes, reactive cytoplasmic changes, reactive nuclear enlargement, subepithelial edema and erosions
● Similar changes occur after radiation therapy and in some patients with scleroderma

Micro images
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Various images

Celiac disease

End of Stomach > Gastritis > Collagenous gastritis

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