Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Stomach

Polyps

Cowden’s syndrome


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 29 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Also known as multiple hamartoma syndrome
● Due to rare autosomal dominant germline mutation in PTEN on 10q23
● Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35-40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas

Gross description
=========================================================================

● Small (1-2 mm), sessile polyps

Micro description
=========================================================================

● Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa

Micro images
=========================================================================



Gastric and colonic polyps

End of Stomach > Polyps > Cowden’s syndrome


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).