Stomach
Polyps
Cowden's syndrome

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 December 2016, last major update August 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: cowden's syndrome
Cite this page: Cowden's syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachcowdens.html. Accessed December 4th, 2016.
Definition / General
  • Also known as multiple hamartoma syndrome
  • Due to rare autosomal dominant germline mutation in PTEN on 10q23
  • Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35 - 40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas
Gross Description
  • Small (1 - 2 mm), sessile polyps
Micro Description
  • Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa
Micro Images

Images hosted on other servers:

Gastric and colonic polyps