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Cowden’s syndrome

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 29 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Also known as multiple hamartoma syndrome
● Due to rare autosomal dominant germline mutation in PTEN on 10q23
● Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35-40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas

Gross description

● Small (1-2 mm), sessile polyps

Micro description

● Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa

Micro images

Gastric and colonic polyps

End of Stomach > Polyps > Cowden’s syndrome

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