Cowden's syndrome

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: cowden's syndrome
Cite this page: Cowden's syndrome. website. Accessed November 18th, 2018.
Definition / general
  • Also known as multiple hamartoma syndrome
  • Due to rare autosomal dominant germline mutation in PTEN on 10q23
  • Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35 - 40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas
Gross description
  • Small (1 - 2 mm), sessile polyps
Microscopic (histologic) description
  • Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa
Microscopic (histologic) images

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Gastric and colonic polyps