Crohn's disease

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Crohn's disease gastritis
Cite this page: Crohn's disease. website. Accessed November 14th, 2018.
Definition / general
  • Clinical involvement rare, microscopic disease is more common
  • Gastric granulomas in 9-15%
  • High proportion of Crohn's patients show upper GI involvement,usually antral (Virchows Arch 1998;432:49)
  • Focal acute inflammation in a background of non-inflamed, H. pylori negative mucosa is suggestive of Crohn's disease (Am J Surg Pathol 1998;22:383, Gut 1996;38:379)
  • Active inflammation in 56% (some inflammatory changes in up to 70%), but only 10% are H. pylori positive
Microscopic (histologic) images

Images hosted on other servers:

Focal lesion in atral mucosa resembling active Crohn's disease

Differential diagnosis
  • Granulomas:
    • Foreign-body
    • Fungus
    • Granulomatous gastritis
    • Sarcoid
    • Tuberculosis
    • Tumor
    • Whipple’s disease