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Crohn’s disease

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 2 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Clinical involvement rare, microscopic disease is more common
● Gastric granulomas in 9-15%
● High proportion of Crohn's patients show upper GI involvement,usually antral (Virchows Arch 1998;432:49)
● Focal acute inflammation in a background of non-inflamed, H. pylori negative mucosa is suggestive of Crohn’s disease (Am J Surg Pathol 1998;22:383, Gut 1996;38:379)
● Active inflammation in 56% (some inflammatory changes in up to 70%), but only 10% are H. pylori positive

Micro images

Crohn's disease of the stomach with focally enhanced gastritis

Focal lesion in atral mucosa resembling active Crohn's disease

Differential diagnosis

● Foreign-body
● Fungus
● Granulomatous gastritis
● Sarcoid
● Tuberculosis
● Tumor
● Whipple’s disease

End of Stomach > Gastritis > Crohn’s disease

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