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Cronkhite-Canada syndrome

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 8 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Very rare juvenile polyposis disorder with diffuse GI polyposis, alopecia, hyperpigmentation, dystrophic changes in fingernails and toenails
● Non-hereditary, unknown etiology
● Onset usually in middle-aged adults
● Patients may have diarrhea, weight loss, abdominal pain, anorexia, weakness, hematochezia
● Occasionally gastric adenocarcinoma, adenocarcinoma anywhere in GI tract (Am J Surg Pathol 1985;9:65)

Case reports

● With alopecia and CMV infection (Arch Pathol Lab Med 1977;101:432)

Micro description

● Polyp with broad sessile base, expanded edematous lamina propria, cystic glands (Am J Surg Pathol 1989;13:940)

Differential diagnosis

● Juvenile polyps
● Ménétrier’s disease: need endoscopic findings and clinical history

End of Stomach > Polyps > Cronkhite-Canada syndrome

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