Cronkhite-Canada syndrome

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: cronkhite-canada syndrome
Cite this page: Cronkhite-Canada syndrome. website. Accessed December 11th, 2018.
Definition / general
  • Very rare juvenile polyposis disorder with diffuse GI polyposis, alopecia, hyperpigmentation, dystrophic changes in fingernails and toenails
  • Nonhereditary, unknown etiology
  • Onset usually in middle age adults
  • Patients may have diarrhea, weight loss, abdominal pain, anorexia, weakness, hematochezia
  • Occasionally gastric adenocarcinoma, adenocarcinoma anywhere in GI tract (Am J Surg Pathol 1985;9:65)
Case reports
Microscopic (histologic) description
Differential diagnosis