Diffuse large B-cell lymphoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 15 December 2016, last major update September 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: gastric diffuse large b-cell lymphoma
Cite this page: Diffuse large B-cell lymphoma. website. Accessed December 11th, 2018.
Definition / general
  • High grade B-cell tumor (Am J Surg Pathol 2003;27:790)
  • May arise from transformed extranodal marginal zone (MALT) lymphoma
  • Usually > age 50 years
  • 5 year survival is 65% (related to stage)
  • Coexistence of MALT lymphoma and diffuse large B-cell lymphoma: do not report as "high grade MALT" (MALT is usually indolent); report instead as diffuse large B-cell lymphoma with coexisting MALT lymphoma
Prognostic factors
Case reports
Gross description
  • Large polypoid or lobulated mass with superficial or deep ulceration; often in distal stomach, but sparing pylorus
Microscopic (histologic) description
  • Infiltrative pattern of high grade, centroblast like cells; multinucleated forms may resemble Reed-Sternberg cells
Positive stains
Differential diagnosis
  • Undifferentiated carcinoma: continuity between tumor cells and epithelium, acinar pattern, muscularis mucosa destruction, positive for keratin and mucin