Stomach - Follicular dendritic cell sarcoma

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Stomach

Stromal / other tumors

Follicular dendritic cell sarcoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 9 October 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Extremely rare
● Behaves like an intermediate-grade soft tissue sarcoma

Case reports
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● 45 year old man with submucosal tumor (Arch Pathol Lab Med 2000;124:1693)

Micro description
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● Fascicular or storiform patterns of spindle and epithelioid tumor with individually scattered and perivascular aggregates of lymphocytes
● Cells have indistinct cell borders / syncytial appearance

Micro images
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Various images

Positive Stains
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● CD21, CD23, CD35

Negative Stains
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● CD31, CD34, c-kit, HMB45

Electron microscopy images
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Long, slender, interweaving cytoplasmic processes focally connected by desmosomal cell junctions

Differential diagnosis
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● GIST: less eosinophilic cytoplasm, c-kit+, DOG1+
● Leiomyosarcoma
● MPNST
● Sarcomatoid carcinoma: usually fungating mass, keratin+, CD21-, CD23-, CD35-

End of Stomach > Stromal / other tumors > Follicular dendritic cell sarcoma

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