Fundic gland polyp
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 24 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Single or multiple small (2 mm) polypoid projections in gastric fundus / body
● Considered to be hamartomas or peculiar form of hyperplastic polyp
● Either sporadic or associated with familial adenomatosis polyposis syndrome, tuberous sclerosis
● Multiple polyps associated with protein pump inhibitors
● Fundic gland cysts are associated with increasing periods of treatment with omeprazole for GERD, and with H. pylori eradication (Hum Pathol 2000;31:684)
● In familial adenomatous polyposis syndrome, occur with increased frequency, 25% are dysplastic vs. 1% of sporadic fundic gland polyps (Am J Surg Pathol 1998;22:293)
● Sporadic cases associated with loss of immunoreactivity for tuberin, a protein altered in tuberous sclerosis (Mod Pathol 2002;15:862)
● Patients with 10+ polyps often have beta-catenin mutations (Mod Pathol 2002;15:718)
Sporadic Fundic Gland Polyposis: A Clinical, Histological, and Molecular Analysis
● Minute mucosal bumps 1-5 mm, usually 1-20, may be part of diffuse fundic gland polyposis (100+ polyps)
50 year old woman taking proton pump inhibitors for 10 years
● Dilated glands / microcysts lined by fundic epithelium
● Shorted foveola, increased smooth muscle in lamina propria, no proliferation of foveolar epithelium
Sporadic fundic gland polyposis
End of Stomach > Polyps > Fundic gland polyp
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