Stomach
Stromal / other tumors
Glomus tumor

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 30 June 2016, last major update July 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: glomus tumor stomach
Cite this page: Glomus tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachglomus.html. Accessed December 4th, 2016.
Definition / General
  • Mesenchymal tumor composed of modified smooth muscle cells; neoplastic counterpart of perivascular glomus bodies
  • Common site is distal extremities; rare in GI tract; most common GI site is stomach
Clinical Features
  • More common in women, median age 55 years (range, 19-90 years, Am J Surg Pathol 2002;26:301)
  • Presents with bleeding (may be life threatening), ulcer symptoms or as incidental finding
  • Much less common than GIST
  • Usually benign, may metastasize to liver and cause death; malignant behavior more likely if > 5 cm, but cannot predict based on histology
Radiology Images

Images hosted on PathOut server:

Case of the Week #393:

53 year old man

Case Reports
Gross Description
  • 2-5 cm (range, 1.1 to 7 cm) intramural mass, usually antral
  • Circumscribed, often with overlying mucosal ulceration and multinodular
Gross Images

Images hosted on PathOut server:

Case of the Week #393:

53 year old man

Micro Description
  • Multiple cellular nodules often separated by streaks of gastric smooth muscle
  • Glomus cells are round, sharply demarcated, with cytoplasmic clearing
  • Hyaline and myxoid change often in center of tumor
  • Mildly dilated pericytoma-like vessels
  • Vascular invasion and focal atypia common
  • 1-4 mitotic figures / 50 HPF
Micro Images

Images hosted on PathOut server:

Case of the Week #393:



Images hosted on other servers:

Various images

Positive Stains
Negative Stains
Electron Microscopy Description
  • Cytoplasm packed with myofilaments with focal condensations
  • Resembles smooth muscle cells
Differential Diagnosis
  • Carcinoid: less prominent cell borders, coarser chromatin, keratin+, chromogranin+, synaptophysin+
  • Epithelioid GIST: pericellular clearing, polygonal and not oval / round, less prominent veins / capillaries
  • Hemangiopericytoma / solitary fibrous tumor: very rare in GI tract, actin-
  • Paraganglioma: zellballen surrounded by sustentacular cells; chromogranin+, synaptophysin+, S100+