Stomach
Carcinoma
Hepatoid adenocarcinoma


Topic Completed: 1 August 2012

Revised: 21 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: stomach hepatoid adenocarcinoma

Elliot Weisenberg, M.D.
Page views in 2018: 1,180
Page views in 2019 to date: 734
Cite this page: Weisenberg E. Hepatoid adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachhepatoid.html. Accessed July 23rd, 2019.
Definition / general
  • Subtype with hepatocellular differentiation and poor prognosis
Gross description
  • Nodular or massive growth, extensive venous invasion
Microscopic (histologic) description
  • Glandular and hepatocellular differentiation
  • Abundant cytoplasmic glycogen, hyaline globules
  • May have tubulopapillary pattern with clear cells
  • May secrete bile
Positive stains
  • AFP in serum
  • Hepatic paraffin antigen AFP (50%, positive in classic gastric adenocarcinomas also)
  • Polyclonal CEA (canalicular pattern)
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