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Hepatoid adenocarcinoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Subtype with hepatocellular differentiation and poor prognosis

Gross description

● Nodular or massive growth, extensive venous invasion

Micro description

● Glandular and hepatocellular differentiation
● Abundant cytoplasmic glycogen, hyaline globules
● May have tubulopapillary pattern with clear cells
● May secrete bile

Positive stains

● Polyclonal CEA (canalicular pattern)
● Hepatic paraffin antigen AFP (50%, positive in classic gastric adenocarcinomas also)
● AFP also in serum

End of Stomach > Carcinoma > Hepatoid adenocarcinoma

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