Hepatoid adenocarcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 9 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: stomach hepatoid adenocarcinoma
Cite this page: Hepatoid adenocarcinoma. website. Accessed October 18th, 2018.
Definition / general
  • Subtype with hepatocellular differentiation and poor prognosis
Gross description
  • Nodular or massive growth, extensive venous invasion
Microscopic (histologic) description
  • Glandular and hepatocellular differentiation
  • Abundant cytoplasmic glycogen, hyaline globules
  • May have tubulopapillary pattern with clear cells
  • May secrete bile
Positive stains
  • AFP in serum
  • Hepatic paraffin antigen AFP (50%, positive in classic gastric adenocarcinomas also)
  • Polyclonal CEA (canalicular pattern)