Hypertrophic gastropathy and enlarged mucosal folds
Hypertrophic hypersecretory gastropathy

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 6 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: hypertrophic hypersecretory gastropathy
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Cite this page: Hypertrophic hypersecretory gastropathy. website. Accessed January 22nd, 2019.
Definition / general
  • Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration that is not associated with gastrin secreting tumor
  • Very rare
  • Cases with protein loss resemble Menetrier's disease, but also have hypergastrinemia
  • Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
  • May be caused by parietal cells that are overly sensitive to normal serum gastrin levels
Microscopic (histologic) description
  • Glandular hyperplasia with normal foveolae
  • May have peptic ulcer disease