Stomach
Hypertrophic gastropathy and enlarged mucosal folds
Hypertrophic hypersecretory gastropathy

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 6 December 2016, last major update August 2012

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PubMed Search: hypertrophic hypersecretory gastropathy
Cite this page: Hypertrophic hypersecretory gastropathy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachhypertrophichypersec.html. Accessed March 26th, 2017.
Definition / General
  • Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration that is not associated with gastrin secreting tumor
  • Very rare
  • Cases with protein loss resemble Menetrier's disease, but also have hypergastrinemia
  • Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
  • May be caused by parietal cells that are overly sensitive to normal serum gastrin levels
Micro Description
  • Glandular hyperplasia with normal foveolae
  • May have peptic ulcer disease