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Stomach

Hypertrophic gastropathy and enlarged mucosal folds

Hypertrophic hypersecretory gastropathy

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 October 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration, that is not associated with gastrin-secreting tumor
● Very rare
● Cases with protein loss resemble Menetrier’s disease, but also have hypergastrinemia
● Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
● May be caused by parietal cells that are overly sensitive to normal serum gastrin levels

Micro description
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● Glandular hyperplasia with normal foveolae
● May have peptic ulcer disease

End of Stomach > Hypertrophic gastropathy and enlarged mucosal folds > Hypertrophic hypersecretory gastropathy

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