Inflammatory fibroid polyp

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 5 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: inflammatory fibroid polyp
Cite this page: Inflammatory fibroid polyp. website. Accessed March 23rd, 2017.
Definition / General
  • Formerly called eosinophilic granuloma
  • Nonneoplastic / benign polyp that occurs anywhere in GI tract, but most common in stomach and small intestine
  • Usually 50 - 60 years old
  • Associated with achlorhydria, hypochlorhydria, pyloric obstruction
  • Usually antral
  • May occlude pyloric channel
  • Rarely associated with adenocarcinoma or adenoma (Arch Pathol Lab Med 1988;112:829)
  • Local excision
Gross Description
  • Sessile or pedunculated
  • Median size 1.5 cm, largest was 9 cm
Micro Description
  • Submucosal lesion with whorls of granulation tissue-like vessels, fibroblastic cells and prominent inflammatory response, primarily eosinophils
  • Also plasma cells and mast cells
  • Minimal mitotic activity
Micro Images

Images hosted on other servers:



Inflammatory fibroid polyp
showing a granulation
tissue-like stroma

Negative Stains
  • CD117 (although mast cells are CD117+), S100