Stomach - Inflammatory fibroid polyp

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Stomach

Polyps

Inflammatory fibroid polyp

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 8 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Formerly called eosinophilic granuloma
● Non-neoplastic / benign polyp that occurs anywhere in GI tract, but most common in stomach and small intestine
● Usually 50-60 years old
● Associated with achlorhydria, hypochlorhydria, pyloric obstruction
● Usually antral
● May occlude pyloric channel
● Rarely associated with adenocarcinoma or adenoma (Arch Pathol Lab Med 1988;112:829)

Treatment
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● Local excision

Gross description
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● Sessile or pedunculated
● Median size 1.5 cm, largest was 9 cm

Micro description
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● Submucosal lesion with whorls of granulation tissue-like vessels, fibroblastic cells and prominent inflammatory response, primarily eosinophils
● Also plasma cells and mast cells
● Minimal mitotic activity

Micro images
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Various images

CD34

CD117

Positive stains
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● Vimentin (100%), CD34, variable smooth muscle actin, HHF-35, fascin, CD35, cyclin D1, calponin

Negative stains
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● CD117 (although mast cells are CD117+), S100

Additional references
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● Am J Surg Pathol 1993;17:1159, Mod Pathol 2000;13:1134, Mod Pathol 2003;16:366

End of Stomach > Polyps > Inflammatory fibroid polyp

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