Stomach
Polyps
Juvenile polyp

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 5 December 2016, last major update August 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: gastric juvenile polyp
Cite this page: Juvenile polyp. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachjuvenile.html. Accessed October 20th, 2017.
Definition / general
  • Also called retention polyp
  • Part of generalized juvenile polyposis coli or rare gastric subtype, 20 - 50% of patients with syndrome have gastric polyps
  • Syndrome due to genetic dysregulation of TGF-β pathway
  • Associated with increased risk of colorectal and gastric carcinoma
Gross description
  • Smooth surfaced, 1 - 2 cm, short narrow stalk
Microscopic (histologic) description
  • Irregular cysts in lamina propria with normal gastric epithelium
  • Surface and foveolar hyperplasia, may have stromal hemorrhage, surface ulceration and chronic inflammation due to torsion
Microscopic (histologic) images

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Gastric juvenile polyp

Differential diagnosis
  • Hyperplastic polyp: usually background mucosal disease, may need clinical or family history for definitive diagnosis