Other nonneoplastic lesions
Kayexelate damage

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 November 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: kayexelate injury
Cite this page: Weisenberg, E. Kayexelate damage. website. Accessed December 11th, 2018.
Definition / general
  • Kayexelate (sodium polystyrene sulfonate) in sorbitol, used to treat hyperkalemia, may crystallize in stomach and produce endoscopic findings resembling gastric bezoar (Am J Surg Pathol 2001;25:637)
  • May produce ulcer or erosion in esophagus, stomach or duodenum
  • Rarely causes colonic infarction
Microscopic (histologic) description
  • Crystals are lightly basophilic with a faint crystalline mosaic pattern, better seen with PAS / Alcian blue
  • Crystals are refractile but not polarizable, luminal and adherent to intact surface epithelium or mixed with inflammatory exudates in patients with ulcer or erosion