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Other non-neoplastic lesions

Kayexelate damage

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 6 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Kayexelate (sodium polystyrene sulfonate) in sorbitol, used to treat hyperkalemia, may crystallize in stomach and produce endoscopic findings resembling gastric bezoar (Am J Surg Pathol 2001;25:637)
● May produce ulcer or erosion in esophagus, stomach, or duodenum
● Rarely causes colonic infarction

Micro description

● Crystals are lightly basophilic with a faint crystalline mosaic pattern, better seen with PAS/Alcian blue
● Crystals are refractile but not polarizable, luminal and adherent to intact surface epithelium or mixed with inflammatory exudates in patients with ulcer or erosion

End of Stomach > Other non-neoplastic lesions > Kayexelate damage

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