Cite this page: Weisenberg, E. Kayexelate damage. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stomachkayexelate.html. Accessed December 11th, 2018.
Definition / general
- Kayexelate (sodium polystyrene sulfonate) in sorbitol, used to treat hyperkalemia, may crystallize in stomach and produce endoscopic findings resembling gastric bezoar (Am J Surg Pathol 2001;25:637)
- May produce ulcer or erosion in esophagus, stomach or duodenum
- Rarely causes colonic infarction
Microscopic (histologic) description
- Crystals are lightly basophilic with a faint crystalline mosaic pattern, better seen with PAS / Alcian blue
- Crystals are refractile but not polarizable, luminal and adherent to intact surface epithelium or mixed with inflammatory exudates in patients with ulcer or erosion