Stromal / other tumors

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 3 October 2017, last major update September 2017

Copyright: (c) 2017,, Inc.

PubMed Search: stomach leiomyosarcoma [title]
Cite this page: Gonzalez, R. S. Leiomyosarcoma. website. Accessed July 23rd, 2018.
Definition / general
  • Malignant smooth muscle sarcoma that arises from the muscularis propria of the stomach
  • Accounts for 1% of all malignant tumors of the stomach
Clinical features
Prognostic factors
Case reports
  • 50 year old woman with hypertension and diabetes presented with a submucosal gastric mass (Case of the Week #438)
Gross images

Images hosted on other servers:

Large gastric leiomyosarcoma (>8 cm)

Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut server, contributed by Dr. Zainab Harb, Salmaniya Medical Complex (Bahrain):

H&E, Case of the Week #438

SMA, COW #438

MSA, COW #438

COW #438

Ki67, COW #438

Positive stains
Negative stains
Board review question #1
Which of the following is a poor prognostic indicator for this neoplasm?

A. Greater than 20 mitoses per 10 high power fields
B. Ki67 proliferative index above 50%
C. Size greater than 5 cm
D. Tumor necrosis
Board review answer #1
C. Size greater than 5 cm