Topic Completed: 1 September 2012

Minor changes: 15 July 2020

Copyright: 2003-2019,, Inc.

PubMed Search: stomach lymphoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Lymphoma-general. website. Accessed August 8th, 2020.
Definition / general
  • 55 - 75% of primary gastrointestinal lymphomas are gastric
  • Lymphomas are 1 - 7% of gastric malignancies
  • Diffuse large B-cell lymphoma most common, then extranodal marginal zone (MALT) lymphoma
  • Most patients age 60+
  • Clinically resembles carcinoma, but usually better prognosis
  • Associated with erosion (61%), intestinal metaplasia (59%), H. pylori (57%), atrophy (37%), dysplasia (4%) (Arch Pathol Lab Med 2000;124:1628)
Microscopic (histologic) description
  • Diffuse large B-cell lymphoma generally resembles nodal disease
  • Features highly suggestive of low grade lymphoma versus inflammation are dense lymphoid infiltrates with either prominent lymphoepithelial lesions, moderate cytologic atypia or Dutcher bodies (Am J Surg Pathol 1990;14:1087)
Microscopic (histologic) images

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