Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 13 December 2016, last major update September 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: stomach lymphoma
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Cite this page: Lymphoma - General. website. Accessed January 23rd, 2019.
Definition / general
  • 55 - 75% of primary gastrointestinal lymphomas are gastric
  • Lymphomas are 1 - 7% of gastric malignancies
  • Diffuse large B-cell lymphoma most common, then extranodal marginal zone (MALT) lymphoma
  • Most patients age 60+
  • Clinically resembles carcinoma, but usually better prognosis
  • Associated with erosion (61%), intestinal metaplasia (59%), H. pylori (57%), atrophy (37%), dysplasia (4%) (Arch Pathol Lab Med 2000;124:1628)
Microscopic (histologic) description
  • Diffuse large B-cell lymphoma generally resembles nodal disease
  • Features highly suggestive of low grade lymphoma versus inflammation are dense lymphoid infiltrates with either prominent lymphoepithelial lesions, moderate cytologic atypia or Dutcher bodies (Am J Surg Pathol 1990;14:1087)
Microscopic (histologic) images

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