Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 23 November 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: gastric malakoplakia
Cite this page: Malakoplakia. website. Accessed October 18th, 2018.
Definition / general
  • May involve any part of GI tract, very rare
  • Associated with E. coli, Klebsiella, Yersinia, Mycobacteria and R. equi
  • Case report associated with gastric adenocarcinoma (Arch Pathol Lab Med 1978;102:136)
Gross description
  • Slightly elevated plaque with umbilication of overlying mucosa
Microscopic (histologic) description
  • Submucosal histiocytes with cytoplasmic inclusions (Michaelis-Gutmann bodies) that are positive for calcium with von Kossa stain
Electron microscopy description
  • Inclusions have dense central calcified body and concentric alternating rings