Hypertrophic gastropathy and enlarged mucosal folds
Menetrier disease

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 7 September 2018, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Menetrier's disease

Related Topics: Localized Menetrier disease
Cite this page: Menetrier disease. website. Accessed October 20th, 2018.
Definition / general
  • A hyperplastic gastropathy described by Menetrier in 1888 as polyadenomes en nappe
  • Giant mucosal folds involving fundus and body, usually (not always) spares antrum
Clinical features
  • 75% men
  • Mean age 30 - 50s; chronic and severe
  • Children: uncommon; often have CMV or other infection, peripheral eosinophilia
  • Peripheral edema present due to mucosal protein loss, variable weight loss, diarrhea
  • Low acid production even after stimulation
  • Likely due to excessive transforming growth factor alpha with increased signalling of EGFR
  • Grossly and radiologically resembles Zollinger-Ellison syndrome
Gross description
  • Usually affects greater curvature of stomach
  • Markedly hypertrophic gastric folds resembling cerebral convolutions
  • Abrupt transition to normal mucosa
Gross images

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Menetrier disease

Microscopic (histologic) description
  • Marked foveolar hyperplasia, tortuous (corkscrew) and cystically dilated foveolar glands
  • May extend into muscularis mucosa
  • Atrophic glandular compartment
  • Edematous and mildly inflamed lamina propria, may have increased intraepithelial lymphocytes
Differential diagnosis