Large cell neuroendocrine carcinoma
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 28 September 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Mean age 70 years (range 44-92 years), 70% men
● Poorer prognosis than non-neuroendocrine carcinomas
● May have a poor outcome in MEN1 patients (Am J Surg Pathol 1997;21:1075)
● Small cell and large cell neuroendocrine carcinomas have similar prognosis (Arch Pathol Lab Med 1998;122:1010)
● Most gastric carcinomas contain scattered cells (small percentage of tumor) with neuroendocrine differentiation (Arch Pathol Lab Med 1996;120:478) - donít call them neuroendocrine carcinomas
● Ulcerated or fungated
● Solid, organoid, trabecular, pseudoglandular, spindle cell or rosette-like patterns
● Small cell or large cell patterns
End of Stomach > Carcinoma > Large cell neuroendocrine carcinoma
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).