Large cell neuroendocrine carcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 8 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: large cell neuroendocrine carcinoma stomach
Cite this page: Large cell neuroendocrine carcinoma. website. Accessed August 19th, 2018.
Definition / general
  • Mean age 70 years (range 44 - 92 years), 70% men
  • Poorer prognosis than nonneuroendocrine carcinomas
  • May have a poor outcome in MEN1 patients (Am J Surg Pathol 1997;21:1075)
  • Small cell and large cell neuroendocrine carcinomas have similar prognosis (Arch Pathol Lab Med 1998;122:1010)
  • Most gastric carcinomas contain scattered cells (small percentage of tumor) with neuroendocrine differentiation (Arch Pathol Lab Med 1996;120:478) - don't call them neuroendocrine carcinomas
Gross description
  • Ulcerated or fungated
Microscopic (histologic) description
  • Solid, organoid, trabecular, pseudoglandular, spindle cell or rosette-like patterns
  • Small cell or large cell patterns