Poorly differentiated neuroendocrine carcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 7 November 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Poorly differentiated neuroendocrine carcinoma stomach
Cite this page: Weisenberg, E. Poorly differentiated neuroendocrine carcinoma. website. Accessed November 14th, 2018.
Definition / general
  • Mean age 70 years (range 44 - 92 years), 70% men
  • Poorer prognosis than nonneuroendocrine carcinomas
  • May have a poor outcome in MEN1 patients (Am J Surg Pathol 1997;21:1075)
  • Small cell and large cell neuroendocrine carcinomas have similar prognosis (Arch Pathol Lab Med 1998;122:1010)
  • Small cell variant resembles counterpart in lung; has aggressive clinical course but treatment may be effective (J Surg Oncol 2012;106:994)
  • Most gastric carcinomas contain scattered cells (small percentage of tumor) with neuroendocrine differentiation (Arch Pathol Lab Med 1996;120:478) - don't call them neuroendocrine carcinomas
Case reports
Gross description
  • Ulcerated or fungated
Microscopic (histologic) description
  • Solid, organoid, trabecular, pseudoglandular, spindle cell or rosette-like patterns
  • Small cell or large cell patterns
Microscopic (histologic) images

Images hosted on other servers:

Small, round
cells with hyper-
chromatic nuclei