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Large cell neuroendocrine carcinoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 28 September 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Mean age 70 years (range 44-92 years), 70% men
● Poorer prognosis than non-neuroendocrine carcinomas
● May have a poor outcome in MEN1 patients (Am J Surg Pathol 1997;21:1075)
● Small cell and large cell neuroendocrine carcinomas have similar prognosis (Arch Pathol Lab Med 1998;122:1010)
● Most gastric carcinomas contain scattered cells (small percentage of tumor) with neuroendocrine differentiation (Arch Pathol Lab Med 1996;120:478) - donít call them neuroendocrine carcinomas

Gross description

● Ulcerated or fungated

Micro description

● Solid, organoid, trabecular, pseudoglandular, spindle cell or rosette-like patterns
● Small cell or large cell patterns

End of Stomach > Carcinoma > Large cell neuroendocrine carcinoma

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