Oncocytic adenocarcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 9 December 2016, last major update August 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: oncocytic adenocarcinoma gastric
Cite this page: Oncocytic adenocarcinoma. website. Accessed November 18th, 2018.
Definition / general
  • Rare, < 50 cases reported
  • Also called parietal cell / gland carcinoma
  • Elderly patients, ages 58 - 81 years
  • Resemble parietal cells, but antiparietal cell antibodies often nonreactive (Am J Surg Pathol 2002;26:458)
  • Cases from other studies may have parietal cell origin, but need antiparietal cell antibody testing
Microscopic (histologic) description
  • Moderate to well differentiated adenocarcinoma with sheets of cells with abundant eosinophilic, finely granular cytoplasm resembling parietal cells
Positive stains
Negative stains
Electron microscopy description
  • Abundant mitochondria, tubulovesicles, intracellular canaliculi, intercellular lumina with long microvilli