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Oncocytic adenocarcinoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 28 September 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Rare, <50 cases reported
● Also called parietal cell/gland carcinoma
● Elderly patients, ages 58-81 years
● Resemble parietal cells, but antiparietal cell antibodies often nonreactive (Am J Surg Pathol 2002;26:458)
● Cases from other studies may have parietal cell origin, but need antiparietal cell antibody testing

Micro description

● Moderate to well differentiated adenocarcinoma with sheets of cells with abundant eosinophilic, finely granular cytoplasm resembling parietal cells

Positive stains

● PTAH, Luxol fast blue

Negative stains

● PAS, Alcian blue, MUC2 (rare cells may be positive)

Electron microscopy description

● Abundant mitochondria, tubulovesicles, intracellular canaliculi, intercellular lumina with long microvilli

End of Stomach > Carcinoma > Oncocytic adenocarcinoma

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