Oncocytic adenocarcinoma

Topic Completed: 1 August 2012

Revised: 21 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: oncocytic adenocarcinoma gastric

Elliot Weisenberg, M.D.
Page views in 2018: 673
Page views in 2019 to date: 368
Cite this page: Weisenberg E. Oncocytic adenocarcinoma. website. Accessed July 21st, 2019.
Definition / general
  • Rare, < 50 cases reported
  • Also called parietal cell / gland carcinoma
  • Elderly patients, ages 58 - 81 years
  • Resemble parietal cells, but antiparietal cell antibodies often nonreactive (Am J Surg Pathol 2002;26:458)
  • Cases from other studies may have parietal cell origin, but need antiparietal cell antibody testing
Microscopic (histologic) description
  • Moderate to well differentiated adenocarcinoma with sheets of cells with abundant eosinophilic, finely granular cytoplasm resembling parietal cells
Positive stains
Negative stains
Electron microscopy description
  • Abundant mitochondria, tubulovesicles, intracellular canaliculi, intercellular lumina with long microvilli
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