Other nonneoplastic lesions
Heterotopic pancreas / pancreatic acinar metaplasia

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 2 November 2018, last major update July 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: heterotopic pancreas
Cite this page: Weisenberg, E. Heterotopic pancreas / pancreatic acinar metaplasia. website. Accessed November 14th, 2018.
Definition / general
Case reports
Gross description
  • Nipple-like projection (with duct emptying into gastric lumen), symmetric cone or round mass
  • Cut surface resembles normal pancreas, but may be cystic
Microscopic (histologic) description
  • Pancreatic acini and ducts usually present (total heterotopia), ducts often dilated, islets present in 30%
  • Rarely endocrine only (case report at Arch Pathol Lab Med 2002;126:464)
  • May have mucocele-like changes
  • Usually in submucosa or muscularis propria
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
  • Lipase, trypsinogen, amylase