Non-neoplastic anomalies
Heterotopic pancreas / pancreatic acinar metaplasia

Authors: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 November 2016, last major update July 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: heterotopic pancreas
Cite this page: Heterotopic pancreas / pancreatic acinar metaplasia. website. Accessed April 24th, 2017.
Definition / General
Case Reports
Gross Description
  • Nipple-like projection (with duct emptying into gastric lumen), symmetric cone or round mass
  • Cut surface resembles normal pancreas, but may be cystic
Micro Description
  • Pancreatic acini and ducts usually present (total heterotopia), ducts often dilated, islets present in 30%
  • Rarely endocrine only (case report at Arch Pathol Lab Med 2002;126:464)
  • May have mucocele-like changes
  • Usually in submucosa or muscularis propria
Micro Images

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Various images

Positive Stains
  • Lipase, trypsinogen, amylase